Clinical features of adolescents with chronic idiopathic or spontaneous urticaria
نویسندگان
چکیده
منابع مشابه
Omalizumab for the treatment of chronic idiopathic or spontaneous urticaria.
BACKGROUND Many patients with chronic idiopathic urticaria (also called chronic spontaneous urticaria) do not have a response to therapy with H-antihistamines, even at high doses. In phase 2 trials, omalizumab, an anti-IgE monoclonal antibody [corrected] that targets IgE and affects mast-cell and basophil function, has shown efficacy in such patients. METHODS In this phase 3, multicenter, ran...
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Skin tests with autologous serum elicit an immediate wheal-and-flare response in about 30-50% of chronic idiopathic urticaria subjects, suggesting that an autoimmune mechanism might be involved in the pathogenesis of this disease. The aim of the present work, involving 68 subjects with chronic idiopathic urticaria, was to distinguish between the serum-positive and serum-negative cases and highl...
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BACKGROUND/AIMS Chronic urticaria (CU) is defined as itchy wheals lasting 6 weeks or more. As the aged population increases worldwide, it is essential to identify the specific features of this disease in the elderly population. METHODS We investigated the prevalence and clinical features of CU in elderly patients. Medical records of 837 CU patients from the outpatient Allergy Clinic of Ajou U...
متن کاملGene expression profiles in chronic idiopathic (spontaneous) urticaria
BACKGROUND The pathophysiology of chronic idiopathic (spontaneous) urticaria (CIU) is poorly understood. OBJECTIVE We hypothesized that a study of gene expression in active lesions from patients with CIU would uncover unexpected associations. METHODS We enrolled eight patients with CIU and six healthy controls, and obtained 4 mm punch biopsy specimens of active lesions and unaffected skin o...
متن کاملChronic idiopathic urticaria treatment.
Chronic idiopathic urticaria (CIU) is a common skin condition that affects 0.1-3 % of people in the USA and Europe and accounts for nearly 75 % of all chronic urticaria cases. Up to 40 % of patients who have chronic urticaria for more than 6 months still have urticarial wheals 10 years later. The therapeutic management should first be oriented towards palliation of symptoms. A 2 % solution of e...
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ژورنال
عنوان ژورنال: Annals of Allergy, Asthma & Immunology
سال: 2017
ISSN: 1081-1206
DOI: 10.1016/j.anai.2017.02.003